Researchers from Qingdao, China, have identified L-shaped dose-response relationships between three markers of vitamin D status and cognitive performance in the elderly. This hadn’t been explored previously and has enabled the scientists to propose referable values of dietary vitamin D intake, serum 25-hydroxyvitamin D3 (25(OH)D3) and total 25-hydroxyvitamin (25(OH)D) for protecting cognitive performance.
“The study found that dietary vitamin D intake, serum total 25(OH)D and 25(OH)D3 concentration were negatively associated with low cognitive performance and risk, and linear L-shaped dose-response relationships between them were identified,” wrote the researchers, in the journal Nutrients.
Dementia: a growing global challenge
As life expectancy increases, cognitive performance decline in the elderly has become a major global public health challenge. According to the WHO, the number of people living with dementia is expected to triple to 152 million by 2050. As vitamin D is neuroprotective, anti-inflammatory and antioxidant, it is considered to be one of the protective factors for cognitive performance.
Dietary vitamin D intake and serum 25-hydroxyvitamin D (25(OH)D) are commonly used to assess vitamin D status. Several studies have looked at the relationships between vitamin D intake and serum 25(OH)D on cognition, but the association remains controversial. Moreover, the dose-response relationship has not been explored - an area that is important to understand as the varying chemical construction and physiological activities of these vitamin D markers might have different effects on cognition.
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September 07, 2021 at 04:22PM
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“Positive associations” found between vitamin D and cognition in elderly - NutraIngredients.com
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